The ideas for COPLA® have been studied in various pre-clinical studies, which has produced several scientific publications and one PhD Thesis. Links to the publications can be found below.
Summary of pre-clinical findings related to COPLA®
- The COPLA® structure enables immediate mobility after surgery
- It has demonstrated the potential for good cartilage and cartilage-bone lesion filling in a short time
- The COPLA® repaired tissue quantity and quality are enhanced parallel to increasing weight-bearing properties of the repaired site
- The COPLA® structure serves as an exceptional substrate for various joint-relevant cell types facilitating targeted tissue growth
- The COPLA® structure’s properties combined with the biological milieu in the joint create a unique combination of optimal load transfer and effective fluid transduction in the damaged area
In short, the COPLA® structure empowers cartilage regeneration and joint preservation.
- Salonius E et al., Cartilage repair capacity within a single full-thickness chondral defect in a porcine autologous matrix-induced chondrogenesis model is affected by the location within the defect. Cartilage. 2021 Dec;13(2_suppl):744S-754S.
- Salonius E et al., Chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells in a three-dimensional environment. J Cell Physiol. 2020 Apr;235(4):3497-3507.
- Gasik M et al., The Importance of Controlled Mismatch of Biomechanical Compliances of Implantable Scaffolds and Native Tissue for Articular Cartilage Regeneration. Front Bioeng Biotechnol. 2018 Nov 30;6:187.
- Muhonen V et al., Articular cartilage repair with recombinant human type II collagen/polylactide scaffold in a preliminary porcine study. J Orthop Res. 2016 May;34(5):745-53.
- Haaparanta AM et al., Preparation and characterization of collagen/PLA, chitosan/PLA, and collagen/chitosan/PLA hybrid scaffolds for cartilage tissue engineering. J Mater Sci Mater Med. 2014 Apr;25(4):1129-36.
- Haaparanta AM et al., The effect of cross-linking time on a porous freeze-dried collagen scaffold using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide as a cross-linker. Journal of Applied Biomaterials & Biomechanics 2008; Vol. 6 no. 2: 89-94.
- Muhonen V., BONE-BIOMATERIAL INTERFACE The Effects of Surface Modified NiTi Shape Memory Alloy on Bone Cells and Tissue, University of Oulu, 2008
- Haaparanta A-M., Highly Porous Freeze-dried Composite Scaffolds for Cartilage and Osteochondral Tissue Engineering, Tampere University of technology, 2015
- Salonius E., The Challenge of Articular Cartilage Repair: Studies on Cartilage Repair in Animal Models and in Cell Culture, University of Helsinki, 2019